I won't go into the gory details of the second worst cold she ever had, but as for the worst one Twilight ever suffered? Well...no one likes to talk about what happened to her long lost big sister, Twilight Sprinkles.
And of course the uber talented
drew this whole thing while fighting off bears and wolverines with nothing but a paper clip and a feather
This also has to be a record for me for being featured on Equestria Daily - same day I posted this, it ends up on EQ. Thanks Sethisto, I was very surprised!